Structural Study in the Platform for Drug Discovery, Informatics, and Structural Life Science

Structural genomics and drug discovery

Structure determination has already proven useful for lead optimization and direct drug design. The number of high-resolution structures available in public databases today exceeds 30,000 and will definitely aid in structure-based drug design. Structural genomics approaches covering whole genomes, topologically similar proteins or gene families are great assets for further progress in the devel...

a structural survey of the polish posters

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Computational and Structural Approaches in Drug Discovery

Accelerated Structural Bioinformatics for Drug Discovery 5

Computer-aided design is one of the critical components of modern drug discovery. Drug development is routinely streamlined using computational approaches to improve hit identification and lead selection, to enhance bioavailability, and to reduce toxicity. In the last decade, a mounting body of genomic knowledge has been accumulated due to advancements in genome-sequencing technologies, present...

Keynote review : Structural biology and drug discovery

895 www.drugdiscoverytoday.com It has long been recognized that knowledge of the 3D structures of proteins has the potential to accelerate drug discovery, but recent developments in genome sequencing, robotics and bioinformatics have radically transformed the opportunities. Many new protein targets have been identified from genome analyses and studied by X-ray analysis or NMR spectroscopy. Stru...